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..Publications
 

Astudillo, A. M., Balboa, M. A. & Balsinde, J. (2018) Selectivity of phospholipid hydrolysis by phospholipase A2 enzymes in activated cells leading to polyunsaturated fatty acid mobilization. Biochim. Biophys. Acta (in press).

Rubio, J. M., Astudillo, A. M., Casas, J., Balboa, M. A. & Balsinde, J. (2018) Regulation of phagocytosis in macrophages by membrane ethanolamine plasmalogens. Front. Immunol. 9: 1723.

Astudillo, A. M., Meana, C., Guijas, C., Pereira, L., Lebrero, P., Balboa, M. A. & Balsinde, J. (2018) Occurrence and biological activity of palmitoleic acid isomers in phagocytic cells. J. Lipid Res 59: 237-249.

Gil-de-Gómez, L., Astudillo, A. M., Lebrero, P., Balboa, M. A. & Balsinde, J. (2017) Essential role for ethanolamine plasmalogen hydrolysis in bacterial lipopolysaccharide priming of macrophages for enhanced arachidonic acid release. Front. Immunol. 8: 1251.  

Lordén, G., Sanjuán-García, I., de Pablo, N., Meana, C., Alvarez-Miguel, I., Pérez-García, M. T., Pelegrín, P., Balsinde, J. & Balboa, M. A. (2017) Lipin-2 regulates NLRP3 inflammasome by affecting P2X7 receptor activation. J. Exp. Med. 214: 511-528.

Peña, L., Meana, C., Astudillo, A. M., Lordén, G., Valdearcos, M., Sato, H., Murakami, M., Balsinde, J. & Balboa, M. A. (2016) Critical role for cytosolic group IVA phospholipase A2 in early adipocyte differentiation and obesity. Biochim. Biophys Acta 1861: 1083-1095.

Guijas, C., Meana, C., Astudillo, A. M., Balboa, M. A. & Balsinde, J. (2016) Foamy monocytes are enriched in cis-7-hexadecenoic fatty acid, 16:1n-9, a possible biomarker for early detection of cardiovascular disease. Cell Chem. Biol. 23: 689-699.

Rubio, J. M., Rodríguez, J. P., Gil-de-Gómez, L., Guijas, C., Balboa, M. A. & Balsinde, J. (2015) Group V secreted phospholipase A2 is up-regulated by interleukin-4 in human macrophages and mediates phagocytosis via hydrolysis of ethanolamine phospholipids. J. Immunol. 194: 3327-3339.

Guijas, C., Rodríguez, J. P., Rubio, J. M., Balboa, M. A. & Balsinde, J. (2014) Phospholipase A2 regulation of lipid droplet formation. Biochim. Biophys. Acta 1841: 1661-1671.

Meana, C., Peña, L., Lordén, G., Esquinas, E., Guijas, C., Valdearcos, M., Balsinde, J. & Balboa, M. A. (2014) Lipin-1 integrates lipid synthesis with proinflammatory responses during TLR activation in macrophages. J. Immunol. 193: 4614-4622.

Gil-de-Gómez, L., Astudillo, A. M., Guijas, C., Magrioti, V., Kokotos, G., Balboa, M. A. & Balsinde, J. (2014) Cytosolic group IVA and calcium-independent group VIA phospholipase A2s act on distinct phospholipid pools in zymosan-stimulated mouse peritoneal macrophages. J. Immunol. 192: 752-762.

Gil-de-Gómez, L., Astudillo, A. M., Meana, C., Rubio, J. M., Guijas, C., Balboa, M. A. & Balsinde, J. (2013) A phosphatidylinositol species acutely generated by activated macrophages regulates innate immune responses. J. Immunol. 190: 5169-5177.

Guijas, C., Pérez-Chacón, G., Astudillo, A. M., Rubio, J. M., Gil-de-Gómez, L., Balboa, M. A. & Balsinde, J. (2012) Simultaneous activation of p38 and JNK by arachidonic acid stimulates the cytosolic phospholipase A2-dependent synthesis of lipid droplets in human monocytes. J. Lipid Res. 53: 2343–2354.

Guijas, C., Astudillo, A. M., Gil-de-Gómez, L, Rubio, J. M., Balboa, M. A. & Balsinde, J. (2012) Phospholipid sources for adrenic acid mobilization in RAW 264.7 macrophages. Comparison with arachidonic acid. Biochim. Biophys. Acta 1821: 1386-1393.

Valdearcos, M., Esquinas, E., Meana, C., Peña, L., Gil-de-Gómez, L., Balsinde, J. & Balboa, M. A. (2012) Lipin-2 reduces proinflammatory signaling induced by saturated fatty acids in macrophages. J. Biol. Chem. 287: 10894-10904.

Astudillo, A. M., Balgoma, D., Balboa, M. A. & Balsinde, J. (2012) Dynamics of arachidonic acid mobilization by inflammatory cells. Biochim Biophys. Acta 1821: 249-256.

Astudillo, A. M., Pérez-Chacón, G., Meana, C., Balgoma, D., Pol, A., del Pozo, M. A., Balboa, M. A. & Balsinde, J. (2011) Altered arachidonate distribution in macrophages from caveolin-1 null mice leading to reduced eicosanoid synthesis. J. Biol. Chem. 286: 35299-35307.

Valdearcos, M., Esquinas, E., Meana, C., Gil-de-Gómez, L., Guijas, C., Balsinde, J. & Balboa, M. A. (2011) Subcellular localization and role of lipin-1 in human macrophages. J. Immunol. 186: 6004-6013.

Astudillo, A. M., Pérez-Chacón, G., Balgoma, D., Gil-de-Gómez, L., Ruipérez, V., Guijas, C., Balboa, M. A. & Balsinde, J. (2011) Influence of cellular arachidonic acid levels on phospholipid remodeling and CoA-independent transacylase activity in human monocytes and U937 cells. Biochim. Biophys. Acta 1811: 97-103.

Balgoma, D., Montero, O., Balboa, M. A. & Balsinde, J. (2010) Lipidomic approaches to the study of phospholipase A2-regulated phospholipid fatty acid incorporation and remodeling. Biochimie 92: 645-650.

Balgoma, D., Astudillo, A. M., Pérez-Chacón, G., Montero, O., Balboa, M. A. & Balsinde, J. (2010) Markers of monocyte activation revealed by lipidomic profiling of arachidonic acid-containing phospholipids. J. Immunol. 184: 3857-3865.

Casas, J., Valdearcos, M., Pindado, J., Balsinde, J. & Balboa, M. A. (2010) The cationic cluster of group IVA phospholipase A2 (Lys488/Lys541/Lys543/Lys544) is involved in translocation of the enzyme to phagosomes in human macrophages. J. Lipid Res. 51: 388-399.

Pérez-Chacón, G., Astudillo, A. M., Ruipérez, V., Balboa, M. A. & Balsinde, J. (2010) Signaling role for lysophospholipid acyltransferase 3 in receptor-regulated arachidonic acid reacylation reactions in human monocytes. J. Immunol. 184:1071-1078.

Pérez-Chacón, G., Astudillo, A. M., Balgoma, D., Balboa, M. A. & Balsinde, J. (2009) Control of free arachidonic acid levels by phospholipases A2 and lysophospholipid acyltransferases. Biochim. Biophys. Acta 1791: 1103-1113.

Casas, J., Meana, C., Esquinas, E., Valdearcos, M., Pindado, J., Balsinde, J. & Balboa, M. A. (2009) Requirement of JNK-mediated phosphorylation for translocation of group IVA phospholipase A2 to phagosomes in human macrophages. J. Immunol. 183: 2767-2774.

Ruipérez, V., Astudillo, A. M., Balboa, M. A. & Balsinde, J. (2009) Coordinate regulation of Toll-like receptor-mediated arachidonic acid mobilization in macrophages by group IVA and group V phospholipase A2s. J. Immunol. 182: 3877-3883.

Balgoma, D., Montero, O., Balboa, M. A. & Balsinde, J. (2008) Calcium-independent phospholipase A2-mediated formation of 1,2-diarachidonoyl-glycerophosphoinositol in human monocytes. FEBS J.  275: 6180-6191.

Balboa, M. A., Pérez, R. & Balsinde, J. (2008) Calcium-independent phospholipase A2 mediates proliferation of human promonocytic U937 cells. FEBS J.  275: 1915-1924.

Pindado, J., Balsinde, J. & Balboa, M. A. (2007) TLR3-dependent induction of nitric oxide synthase in RAW 264.7 macrophage-like cells via a cytosolic phospholipase A2/cyclooxygenase-2 pathway. J. Immunol. 179: 4821-4828.

Ruipérez, V., Casas, J., Balboa, M. A. & Balsinde, J. (2007) Group V phospholipase A2-derived lysophosphatidylcholine mediates cyclooxygenase-2 induction in lipopolysaccharide-stimulated macrophages. J. Immunol. 179: 631-638.

Balsinde, J., Pérez, R. & Balboa, M. A. (2006) Calcium-independent phospholipase A2 and apoptosis. Biochim. Biophys. Acta 1761: 1344-1350.

Balboa, M. A. & Balsinde, J. (2006) Oxidative stress and arachidonic acid mobilization. Biochim. Biophys. Acta 1761: 385-391.

Casas, J., Gijón, M. A., Vigo, A. G., Crespo, M. S., Balsinde, J. & Balboa, M. A. (2006) Overexpression of cytosolic group IVA phospholipase A2 protects cells from calcium-dependent death. J. Biol. Chem. 281: 6106-6116.

Pérez, R., Matabosch, X., Llebaria, A., Balboa, M. A. & Balsinde, J. (2006) Blockade of arachidonic acid incorporation into phospholipids induces apoptosis in U937 promonocytic cells. J. Lipid Res. 47: 484-491.

Pérez, R., Balboa, M. A. & Balsinde, J. (2006) Involvement of group VIA calcium-independent phospholipase A2 in macrophage engulfment of hydrogen peroxide-treated U937 cells. J. Immunol. 176: 2555-2561.

Casas, J., Gijón, M. A., Vigo, A. G., Crespo, M. S., Balsinde, J. & Balboa, M. A. (2006) Phosphatidylinositol 4,5-bisphosphate anchors cytosolic group IVA phospholipase A2 to perinuclear membranes and decreases its calcium requirement for translocation in live cells. Mol. Biol. Cell 17: 155-162.

Balsinde, J. & Balboa, M. A. (2005) Cellular regulation and proposed biological functions of group VIA calcium-independent phospholipase A2 in activated cells. Cell. Signal. 17: 1052-1062.

Pérez, R., Melero, R., Balboa, M. A. & Balsinde, J. (2004) Role of group VIA calcium-independent phospholipase A2 in arachidonic acid release, phospholipid fatty acid incorporation, and apoptosis in U937 cells responding to hydrogen peroxide. J. Biol. Chem. 279: 40385-40391.

Fuentes, L., Pérez, R., Nieto, M. L., Balsinde, J. & Balboa, M. A. (2003) Bromoenol lactone promotes cell death by a mechanism involving phosphatidate phosphohydrolase-1 rather than calcium-independent phospholipase A2. J. Biol. Chem. 278: 44683-44690.

Balboa, M. A., Pérez, R. & Balsinde, J. (2003) Amplification mechanisms of inflammation: paracrine stimulation of arachidonic acid mobilization by secreted phospholipase A2 is regulated by cytosolic phospholipase A2-derived hydroperoxyeicosatetraenoic acid. J. Immunol. 171: 989-994.

Balboa, M. A., Sáez, Y. & Balsinde, J. (2003) Calcium-independent phospholipase A2 is required for lysozyme secretion in U937 promonocytes. J. Immunol. 170: 5276-5280.

Balboa, M. A. & Balsinde, J. (2002) Involvement of calcium-independent phospholipase A2 in hydrogen peroxide-induced accumulation of free fatty acids in human U937 cells. J. Biol. Chem. 277: 40384-40389.

Balsinde, J. (2002) Roles of various phospholipases A2 in providing lysophospholipid acceptors for fatty acid phospholipid incorporation and remodelling. Biochem. J. 364: 695-702.