September 12, 2021 - "The best way to make your dreams come true
is to wake up" (Paul Valéry, French poet). Fall 2021 group meeting schedule
August 30, 2021 - A
study by Chilton and associates appearing in the latest JCI
issue reports elevated plasma levels of group IIA secreted
and related metabolites in severe COVID-19 patients. This work
provides strong evidence that this enzyme may constitute a
therapeutic target to reduce COVID-19 mortality. Why will it be that
we are not surprised in the very least?
August 27, 2021 - One can't endorse a request without even
knowing it. Things come and things go. Quoted for truth.
August 7, 2021 - Current Quotation #32: "When I was a boy of
fourteen, my father was so ignorant I could hardly stand to have the
old man around. But when I got to be twenty-one, I was astonished at
how much the old man had learned in seven years" (Mark Twain,
July 27, 2021 - One would expect that, at least in a biomed lab,
two plus two always equal four. To our dismay, we have come to
realize that some people seem to be intent on disproving even this
July 14, 2021 - Current Quotation #31: "Whoever hides something
is because they have something to hide" (Fernando Esteso, truistic
July 11, 2021 - So many new journals, so many new publishers.
They target your ego, and they do it so well that many times it is
difficult to separate honest science from marketing and pure
July 6, 2021 - Current Quotation #30: "You cannot get to know
and love Italy if you have not tried Spain first" (Italian proverb).
June 30, 2021 - The fair of vanities that is all that impact
factor thing spread its latest essences today. Regarding quartiles,
everything stays more or less the same as in the previous years: the
journals that not long ago were for us 'the journals' are all in Q2,
some even in Q3. Interestingly, many of the new journals have fared
better, with some of them positioning well in Q1. We keep wondering
why people regard these data as as a measure of quality instead of
popularity, which is what it really is. Lost battle, we know.
June 14, 2021 - "A day without football is a wasted day" (Ernst
Happel, Austrian coach). Summer 2021 group meeting schedule
June 13, 2021 - Stearoyl-CoA desaturase-1 and lipidomic
profiling, hypoxic microenvironment and kidney cancer cells, all
together in our latest paper. You may want to look it
June 10, 2021 - Fortunately, the irresponsibility of some will
not have a negative impact on our activities. We will have to wait a
few weeks though to make sure nothing goes awry.
June 7, 2021 - We must face it: some things will never change.
How do you keep going when everything but your pride tells you that
the effort is not worth the benefit?
May 28, 2021 - Today Miguel
Bermúdez brilliantly defended his PhD dissertation, titled
"Regulation of the Inflammatory Response of Macrophages by Lipids:
Roles of Arachidonic and Palmitoleic Acids." Kudos to him for an
May 17, 2021 - Sometimes you spend hours on a problem without
finding a solution. Then, when almost all hope is lost, somehow as
if out of nowhere, you realize the solution was in front of your
May 7, 2021 - Some people settle for the crumbs as a
strategy of resilience. While there are certainly better ways to
overcome adversity, for the time being we will take the money and
April 23, 2021 - You are a foreigner. This changes when they
need something from you. Afterward you
are a foreigner again. The funny thing is that they think you are
April 19, 2021 - Current Quotation #29: "Something is happening
and you don't know what it is. Do you, Mr. Jones?" (Bob Dylan, he
appeared so many times in this section). On a personal note, we wish
we did not know, but hey...
April, 12, 2021 - Not necessarily a waste of resources to try
chasing an artifact, but one has to know where and when to desist.
April 3, 2021 - Current Quotation #28 is an ancient Greek
proverb, and a pretty good one given the current times: "Whom the
gods would destroy they first make mad".
March 27, 2021 - Understanding signaling networks regulated by
lipins provides clues to define the immunometabolic response of
activated macrophages. All this and a bit more at the
annual meeting of the Spanish Society
March 24, 2021 - "Studying without a liking for it spoils the
memory, and it retains nothing it takes in” (Leonardo da Vinci,
Italian polymath). Spring 2021 group meeting schedule
March 23, 2021 - An ancient proverb says that the enemy of your
enemy is your friend. However sometimes it is better to walk alone,
and the current situation is one of those. Uh, and the friends of my
friends are also my friends... what a mess!
March 10, 2021 - Current Quotation #27: "If you look for
different results, don't always do the same" (Attributed to Albert
Einstein, German physicist, Nobel Laureate in Physics 1921).
March 8, 2021 - Current Quotation #26: "Fool me once, shame on
you, fool me twice, shame on me" (ancient saying, likely of Greek or
February 26, 2021 - Like two peas in a pod; cells and
biomolecules, biomolecules and cells.
Phospholipases, from structure
to function, and something in the way they move.
February 19, 2021 - Trying to identify possible arachidonic acid
sources for prostaglandin biosynthesis in zymosan-stimulated
macrophages, and the role of cellular compartmentalization as an
effective means to regulate both the levels and nature of
eicosanoids produced. Soon in your favorite eicosanoid
February 17, 2021 - Current Quotation #25: "Let nothing disturb
you, let nothing frighten you, all things pass away... patience
obtains all things" (St. Teresa of Avila, Spanish mystic).
February 16, 2021 - With the new advances in lipidomics, a
growing number of unusual fatty acids are being detected. A recent
Cell Reports describes desaturase and elongase enzyme activities
that drive the increased diversification of fatty acid isomers in
prostate cancer cell lines and tissues. An abundant presence of
these unconventional fatty acids, including 16:1n-9, is found in
neutral lipids, consistent with our
February 15, 2021 - Sitting back and waiting for the rain to
come is fine as long as the rain finally comes. No rain, no
flowers, yes, but no effort, no reward too.
February 8, 2021 - Stanford University people recently published
PLoS Biology their updated list of the world's top scientists
across all disciplines, based on Scopus citation data. While
bibliometric measures are usually of very limited value, it does not
hurt at all that the Stanford University list includes us among the
most influential biochemists worldwide (he, he).
February 6, 2021 - Our Paper of the
Year 2020 was published last July in Cell Metabolism. Making
good use of lipidomics,
Hsieh et al. showed that distinct proinflammatory stimuli
reshape the macrophage lipid composition in a signal-specific
manner. The study raises the provocative idea that manipulating the
ability of macrophages to adopt their preferred lipidomic state can
be exploited to enhance host defense against bacterial challenge.
January 18, 2021 - "There are three stages of scientific
discovery: first people deny it is true; then they deny it is
important; finally they credit the wrong person" (Alexander von
Humboldt, German geographer). Winter 2021 group meeting schedule
January 15, 2021 - Neverending e-mail exchanges and on-line
meetings, lots of paperwork to achieve in the end the same
result as if we were allowed to decide by ourselves.