May 7, 2021 - Some people settle for the crumbs as a
strategy of resilience. While there are certainly better ways to
overcome adversity, for the time being we will take the money and
April 23, 2021 - You are a foreigner. This changes when they
need something from you. Afterward you
are a foreigner again. The funny thing is that they think you are
April 19, 2021 - Current Quotation #29: "Something is happening
and you don't know what it is. Do you, Mr. Jones?" (Bob Dylan, he
appeared so many times in this section). On a personal note, we wish
we did not know, but hey...
April, 12, 2021 - Not necessarily a waste of resources to try
chasing an artifact, but one has to know where and when to desist.
April 3, 2021 - Current Quotation #28 is an ancient Greek
proverb, and a pretty good one given the current times: "Whom the
gods would destroy they first make mad".
March 27, 2021 - Understanding signaling networks regulated by
lipins provides clues to define the immunometabolic response of
activated macrophages. All this and a bit more at the
annual meeting of the Spanish Society
March 24, 2021 - "Studying without a liking for it spoils the
memory, and it retains nothing it takes in” (Leonardo da Vinci,
Italian polymath). Spring 2021 group meeting schedule
March 23, 2021 - An ancient proverb says that the enemy of your
enemy is your friend. However sometimes it is better to walk alone,
and the current situation is one of those. Uh, and the friends of my
friends are also my friends... what a mess!
March 10, 2021 - Current Quotation #27: "If you look for
different results, don't always do the same" (Attributed to Albert
Einstein, German physicist, Nobel Laureate in Physics 1921).
March 8, 2021 - Current Quotation #26: "Fool me once, shame on
you, fool me twice, shame on me" (ancient saying, likely of Greek or
February 26, 2021 - Like two peas in a pod; cells and
biomolecules, biomolecules and cells.
Phospholipases, from structure
to function, and something in the way they move.
February 19, 2021 - Trying to identify possible arachidonic acid
sources for prostaglandin biosynthesis in zymosan-stimulated
macrophages, and the role of cellular compartmentalization as an
effective means to regulate both the levels and nature of
eicosanoids produced. Soon in your favorite eicosanoid
February 17, 2021 - Current Quotation #25: "Let nothing disturb
you, let nothing frighten you, all things pass away... patience
obtains all things" (St. Teresa of Avila, Spanish mystic).
February 16, 2021 - With the new advances in lipidomics, a
growing number of unusual fatty acids are being detected. A recent
Cell Reports describes desaturase and elongase enzyme activities
that drive the increased diversification of fatty acid isomers in
prostate cancer cell lines and tissues. An abundant presence of
these unconventional fatty acids, including 16:1n-9, is found in
neutral lipids, consistent with our
February 15, 2021 - Sitting back and waiting for the rain to
come is fine as long as the rain finally comes. No rain, no
flowers, yes, but no effort, no reward too.
February 8, 2021 - Stanford University people recently published
PLoS Biology their updated list of the world's top scientists
across all disciplines, based on Scopus citation data. While
bibliometric measures are usually of very limited value, it does not
hurt at all that the Stanford University list includes us among the
most influential biochemists worldwide (he, he).
February 6, 2021 - Our Paper of the
Year 2020 was published last July in Cell Metabolism. Making
good use of lipidomics,
Hsieh et al. showed that distinct proinflammatory stimuli
reshape the macrophage lipid composition in a signal-specific
manner. The study raises the provocative idea that manipulating the
ability of macrophages to adopt their preferred lipidomic state can
be exploited to enhance host defense against bacterial challenge.
January 18, 2021 - "There are three stages of scientific
discovery: first people deny it is true; then they deny it is
important; finally they credit the wrong person" (Alexander von
Humboldt, German geographer). Winter 2021 group meeting schedule
January 15, 2020 - Neverending e-mail exchanges and on-line
meetings, lots of paperwork to achieve in the end the same
result as if we were allowed to decide by ourselves. Some things will never change. The funny thing is that
there is no reason for them not to change.
December 29, 2020 - Group V phospholipase A2
is known to participate in a number of functions of macrophages
exposed to interleukin-4, which polarizes the cells to an
anti-inflammatory phenotype. In the last article of the
Biomolecules special issue on Phospholipases, Koganesawa et al.
performed a mass spectrometry analysis of phospholipase A2
products and substrates, using macrophages deficient or not in the
group V enzyme, and polarized to either anti-inflammatory
(interleukin-4-treated) or pro-inflammatory (lipopolysaccharide plus
study identified selective changes between the different
activation regimes, suggesting the existence of novel lipid pathways
and functions critical for inflammation that may rely on the group V
December 17, 2020 - Current Quotation #24: "I do not speak of
revenge or forgiveness, forgetting is the only revenge and the only
forgiveness" (Jorge Luis Borges, Argentinian writer).
December 14, 2020 - Little by little, we are making inroads into
fields never plowed. Whether the harvest will be abundant or paltry
in the fall it is yet too soon to predict.
December 3, 2020 - Current Quotation #23: "If you lie down with
dogs, you get up with fleas" (English proverb). Nothing can be done
about it, but still no way out.