May 5, 2022 - The latest installment of the specialized
pro-resolving mediator controversy (see March 9 entry) has reached
unexpected heights and is commented on in
Science. Best part, the last sentence: "no one expects an easy
resolution to this highly inflamed dispute."
April 29, 2022 - We just learned that the review paper we published in BBA in June 2019 (this
one) is the journal's most cited
article of the last three years. This is, obviously, a good
thing to note.
April 11, 2022 - Quotation #37 is actually two similar ones,
both from or attributed to Thomas Alva Edison, American inventor and
businessman. "Our greatest weakness lies in giving up; the most
certain way to succeed is always to try just one more time", and
"People are not remembered by the number of times they fail, but by
the number of times they succeed; and the number of times they
succeed is in direct proportion to the number of times they fail and
keep on trying. Every wrong step is another step forward.”
April 6, 2022 - An interesting study published in
Cells suggests that mice may retain cellular memories of
exposure to arachidonic acid across generations. In particular,
continued exposure of the animals to arachidonic acid increases
their content in 16:1n-9, which is quite reminiscent of our own data
showing the up-regulation of this fatty acid in arachidonate-treated
April 1, 2022 - New insights into the interaction of cytosolic
with membrane phosphoinositides. coming soon to your favorite
March 29, 2022 - "Four things cannot be hidden for a long time:
scientific facts, stupidity, wealth, and poverty" (Ibn Rushd,
Averroes, Muslim Spanish philosopher). Spring 2022 group meeting schedule
March 28, 2022 - 15-Hydroxyeicosatetraenoic acid (15-HETE) is
most often regarded as a lipoxygenase metabolite.
However, 15-HETE can also be produced at very significant quantities by cyclooxygenases.
Thus, before taking 15-HETE production as an indicator of
lipoxygenase activity in cells, it would be good to assess its levels in the
presence of a cyclooxygenase inhibitor.
March 24, 2022 - Another
study implicating secreted phospholipase A2
in the pathology of COVID-19. This time is not the group IIA enzyme,
but the group IID. The work is in mice, perhaps that makes the
March 17, 2022 - People often do not pay much attention to the
abbreviations list in a manuscript. Not a good idea if the author
has dedicated a lot of time in preparing it.
March 9, 2022 - The discovery of oxygenated products of
omega-3 fatty acids and their role as resolutory/ant-inflammatory
mediators was always received with much skepticism by the scientific
review just appearing in Frontiers in Pharmacology calls into
question much of the evidence gathered along the years regarding
specialized pro-resolving mediators. As this area of research is
tangential to our work we have no opinion on the subject, but the
review is indubitably a must read.
February 28, 2022 - Current Quotation #36: "Nothing can be
stolen from an empty place" (Spanish proverb). In Dylanian terms,
when you got nothing, you got nothing to lose.
February 15, 2022 - We bring Mead acid (5,8,11-eicosatrienoic
acid) again to this section. It is a non-essential polyunsaturated
fatty acid of the n-9 series that, unusually, carries the name of
its discoverer, James F. Mead. Cultured cell lines are often found
to contain significant amounts of Mead acid. This is thought to
occur to compensate somehow for the low levels of polyunsaturated
fatty acids of the n-6 and n-3 series that cell lines exhibit. For
quick reference, here is our very
nice fatty acid list.
February 7, 2022 - María Zambrano was a writer and philosopher,
widely regarded as one the most brilliant minds of the 20th century
in Spain. She was awarded two of the most important literary prizes
in the Spanish-speaking world, the Cervantes Prize in 1981 and the
Prince of Asturias Prize in 1988, the first woman to receive both
recognitions. We welcome (back) David Balgoma as a
María Zambrano Fellow in the Biomedical Sciences.
January 31, 2021 - In the April issue of Nature Chemical
Kagan and co-workers published a study demonstrating the key
role of group VIA calcium-independent phospholipase A2
in averting ferroptosis by eliminating oxidized phospholipids that
act as ferroptotic signals. It seems like all the pieces of the
puzzle are finally coming together, and the actual biological roles
are finally coming to the spotlight. This is the paper we
distinguished as Paper of the Year 2021.
January 18, 2021 - Current Quotation #35: "I have learned not to
try to convince anyone. The work of convincing is an attempt to
colonize the other" (José Saramago, Portuguese writer, Nobel
Laureate in Literature 1998).
January 14, 2021 - We got
mentioned again in the Lipid Matters blog. This time in a kind
of different way, but hey, as we often say, free exposure is always
January 13, 2021 - "It is not so much that I have confidence in
scientists being right, but that I have so much in nonscientists
being wrong" (Isaac Asimov, American writer and biochemist). Winter 2022 group meeting schedule
December 23, 2021 - This confusing year comes to and end in a
(how come!) confusing manner. "Legal imperative " should be the key
for the next year. Look at the Christmas
greeting card from one of our supporting institutions, the
lesser one yet the easier to deal with. So closes the blog for this
December 10, 2021 - Anything you wanted to know about lipid
droplets, arachidonic acid, phospholipase A2,
and atherosclerosis, coming soon to your favorite eicosanoid
December 3, 2021 - My dear Buenos Aires, when I get to see you
again there will be no more sorrow or oblivion... but hopefully a
lot of interest on phospholipase A2.
December 1, 2021 - Also from Bill Christie's
Lipid blog: "they (IUPAC-IUB) rebuked me for using the generic
term 'cholesteryl esters', which I was told should correctly be
termed 'cholesterol esters'. 'Cholesteryl' should be applied only
when describing individual lipid species, e.g. cholesteryl
palmitate, cholesteryl oleate, etc." It is an old entry (Oct 11,
2017), but we were recently questioned about this.