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February 16, 2024 - Sciadonic acid is a polyunsaturated fatty acid of the n-6 family. It contains 20 carbon atoms and 3 double bonds at C5, C11, and C14. It is the fatty acid that would result of removing the double bond at C8 from arachidonic acid. Because of this structural similarity, sciadonic acid is proposed to compete with arachidonic acid for incorporation into phospholipids, thus displaying an anti-inflammatory character.

February 7, 2024 - The December 2023 issue of the bulletin of the Spanish Biochemical Society (SEBBM) includes a note on our recent paper in EMBO Reports (in Spanish). It had been a long time since we last appeared in the bulletin.

January 31, 2024 - Current quotation #50: "It's much easier to fool people than to convince them that they have been fooled" (Mark Twain, American writer).

January 23, 2024 - Starting today, we move to another ISP, the fourth since this site was published on-line. Primarily economic considerations justified the move.

January 18, 2024 - Current quotation #49: "The difference between something good and something great is attention to detail" (Charles Swindoll, American author).

January 16, 2024 - A recent paper by the group of Walee Chamulitrat in BBA shows that persistent treatment of mice with lipopolysaccharide (LPS) markedly increases pla2g4a mRNA expression. Importantly, a trend and significant further upregulation of pla2g4a was observed in male and female mice lacking pla2g6a, respectively. In other words, the lack of iPLA2β up-regulates cPLA2α... wasn't it about time for someone to report on this? The same paper also shows that "myeloid-specific pla2g6a deficiency leads to the promotion of adaptive autoimmune and LPS-innate inflammatory responses preferentially in male mice associated with an activation of MIP-1α/CCL3." In other words, if the absence of iPLA2β exacerbates inflammation, iPLA2β must serve a major anti-inflammatory role... wasn't this what we have been telling for years?

January 15, 2024 - More on the previous entry. The chain of absurdities that occurred last week is so unbelievably disappointing and at the same time innocent that it may even provoke affection... (hey, just a figure of speech).

January 12, 2024 - (This one is only for Spaniards, sorry) If we had to summarize in a few words what happened to the IBGM in the last two days, it would be these, hands down.

January 11, 2024 - CoA-independent transacylase is an enzyme that transfers arachidonate moieties directly within phospholipids, that is, without using either coenzyme A or ATP. The enzyme activity was described more than 40 years ago, but it was only in March 2023 that its sequence was finally unveiled. Reed et al achieved the feat. They found that the enzyme is the previously uncharacterized transmembrane protein TMEM164 that, not unexpectedly, plays an important role during ferroptosis. This is the paper we distinguish as Paper of the Year 2023.

January 9, 2024 - "Success is an exception. People fight and strive but triumph very once in a while" (Marcelo Bielsa, Argentine soccer coach). Winter 2024 group meeting schedule here.    .  .   .

 

December 22, 2023 - First it was gestational diabetes (sort of), and now it is the microbiota thing. An old Spanish adage states that never sequels were good. Let's see what happens this time. After all, when you got nothing, you got nothing to lose.

December 9, 2023 - Current quotation #48: "I suppose I am proud of what has gone on, after all I only ever wanted to play the guitar for a living, and that is what I am still doing" (Bernie Marsden, English musician).

December 7, 2023 - Faithful to their annual rendezvous with the School of Medicine, the storks start to populate the roofs of the main building. But, as always, these little things that make some people happy also annoy others....

November 29, 2023 - "The detective of cholesterol and triglycerides." Journalists always unleashing their creativity.

November 28, 2023 - As the time for conversation is long over, we are just sitting here watching the wheels go round and round. We really love to watch them roll.

November 23, 2023 - Yesterday, Alvaro Garrido defended his doctoral dissertation, titled "Lipidomic Studies in Macrophages. Role of Lipins in Regulating Phospholipid Levels and Inflammatory Processes." Congrats to him for an excellent performance.

November 20, 2023 - Back from the Annual CIBERDEM meeting. Not much novelty under the Catalan sun this year, except for interesting data on lipin-2 and the mitochondria.

November 14, 2023 - Good things always come in pairs. Another collaborative paper with our CIBERDEM colleagues at the University of Barcelona (Manuel Vázquez Carrera's group) has just appeared in Cell Communication and Signaling.

November 10, 2023 - Lipin-2 is really becoming a master regulator of so many innate immune reactions that... well, it is always fun to talk about it.

November 9, 2023 - Interested in the distribution of docosahexaenoic acid in macrophage phospholipids? Check this out.

November 6, 2023 - The Stanford list of top scientists is here again. Other than  pissing the hell off an old friend of us, we fail to see the purpose of this kind of lists.

November 2, 2023 - Our friends and colleagues at the IMIB in Murcia, bringing again a bit of humor to everyday scientist's life: Dance the Barbie night! Special eye on the wigs.

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