March 14, 2018 - Today the earth and the heavens smile at me; today the sun reaches the bottom of my soul; today I've looked at the calendar... I've looked at it and I have realized that... today's the day! (With thanks to Gustavo Adolfo for the inspiration).

March 7, 2018 - Our recent JLR paper on palmitoleic acid isomers in phagocytic cells is commented upon briefly but very accurately in the Lipid Web blog. This is the third time that our work is mentioned in such a prestigious place. We thank Dr. Christie for the free exposure.

February 20, 2018 - Dennis Vance, another of the lipid research giants of our era, wrote a very enjoyable Reflection article last fall in JBC. In it, we read: "Previously, one could possibly have developed an inhibitor of PEMT (phosphatidylethanolamine N-methyltransferase) that might have revealed the role of PEMT in evolutionary biology. However, there is always concern about incomplete inhibition and off-target effects of inhibitors, whereas gene-targeting technology is very specific and unambiguous." True, of course, but just in the previous paragraph, the author noted that in Pmet-/- animals the amount of the active form of hepatic CTP:phosphocholine cytidylyltransferase is 60% higher than in wild type animals, to maintain phosphatidylcholine levels. So we wonder, could not gene compensations in k.o. animals have an influence on something?

February 16, 2018 - It took quite a bit more than blood, sweat and tears, but our new toy, a QTRAP 4500, the fifth of the series, is home at last. Now it is our turn to see how beautifully this little monster does.

February 13, 2018 - Several years ago it was reported that the orphan receptor GPR120 is an omega-3 fatty acid receptor which mediates the anti-inflammatory and insulin-sensitizing effects of these fatty acids. A very recent paper in Cell Metabolism suggests that other orphan receptor, GP40, is activated by members of the novel family of fatty acid hydroxy fatty acyl esters. Grab some soda and pop corn and get ready to enjoy future works on this engaging subject (no pun intended).

February 9, 2018 - A technological note on lipids just published in Nature Methods caught our eye for its subheading, an ultimate declaration of lipidological principles: "Fats add structure, they signal, they interact. In the lab, lipids are tough to work with but worth the challenge."

February 8, 2018 - Didn't they want some news releases? Here is one: "Novel lipids as possible markers for immunometabolic diseases" in the News section of the official website of CIBER-ISCIII (in Spanish; use the browser's built-in translator).

February 7, 2018 - Some scattered thoughts that cross one's mind after browsing today's press: "let them invent, that later we will take advantage of their inventions. For, I  trust  and  hope  you  will  be  convinced as I am, the electric bulb shines equally well here as in the place where it was invented." Different situation, same idea, here.

January 30, 2018 - Essential fatty acid deficiency, especially for cells in culture, is seldom appreciated. Very few studies have been carried out to document alterations in phospholipid molecular species as a result of serum starvation or depletion of polyunsaturated fatty acids during tissue culture. A nice paper by the Murphy group just appearing in JLR Papers in Press fills the gap, and shows the replacement of arachidonic acid with mead acid in particular phospholipid species as cells are kept in culture, this leading to marked changes in the overall eicosanoid response.

January 27, 2018 - Good things, they say, usually come in threes; omne trium perfectum - everything that comes in threes is perfect. There is lies, damn lies and statistics, the three little pigs, the bad, the good and the ugly... and there is also the education, the science and the future.

January 23, 2018 - This year the trilling blackbirds have taken longer than usual to make themselves noticed. Today, the first day that their singing finally floods the dawn of the city, also come in those who like to make themselves noticed. Preserve your memories, they're all that's left to you.

January 19, 2018 - The flight of Icarus, in addition to being a fine Iron Maiden song, is a great reminder that the wax of reality may melt for so many reasons, and the floor is a very hard place to fall. Recurring thoughts for the day.

January 16, 2018 - Directorial Quotation #40: "One of the penalties for refusing to participate in politics is that you end up being governed by your inferiors" (Plato, Greek philosopher).

January 15, 2018 - Our Paper of the Year 2017 was published in the Nov issue of Nature Medicine by Arai and colleagues. The work describes a new pathway regulated by PAF acetyl hydrolase that results in the generation of omega-3 fatty acid epoxides as new lipid mediators of mast cell-mediated allergic reactions.   .

January 8, 2018 - "Don't try to be a great man, just be a man and let history make its own judgment" (Zephram Cochrane, rocket scientist. Also a Roy Orbison fan) Winter 2018 group meeting schedule here.

December 28, 2017 - Our latest palmitoleic paper (to appear shortly in the JLR) ranks 23rd, out of 43 entries, in the "Most-Read Articles during October thru November 2017" list. Not bad considering that our paper was first published in the Papers in Press section on Nov 21. With this exhilarating news we say goodbye to this year and wait for the next one, which promises to begin in a pretty hectic way.

December 20, 2017 - It has been suggested that titanium exposure may be harmful to the brain, in particular to glial cells, which include the astrocytes. Astrocytes are known as rich sources of arachidonic acid and its oxygenated metabolites. Morale of the story: if your sixth sense says no, get to trust it.   .

December 19, 2017 - Directorial Quotation #39: "You never know what is enough unless you know what is more than enough" (William Blake, English poet).

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